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The most common renal disease in humans is chronic kidney disease (CKD). Oxidative stress is considered as a major factor for the development of CKD and its complications. To evaluate the renal oxidative stress in nephropathy, we measured thiobarbituric acid reactive substance (TBARS), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPx) in the kidneys of nephropathy in adult rat. Male Wistar rats were divided into 4 groups and 2 groups were treated with metallothionein inhibitor, thioridazine (20 mg/kg/day for 6 weeks) and folic acid (15 mg/kg/day for 6 weeks) separately. Renal function markers were evaluated by measuring blood urea nitrogen (BUN), serum creatinine (Cr) and serum urea. For histopathological examination, the samples were stained with hematoxylin-eosin (H&E) and periodic acid Schiff (PAS). The TBARS, SOD, CAT, GSH and GPx levels in the renal tissue were higher (p = 0.001, p = 0.003, p = 0.04, p = 0.04, p = 0.01, respectively) while the Cr and BUN levels were lower (p = 0.001, p = 0.001) than the control group. In the thioridazine group, the SOD, CAT, GSH and GPx levels were lower (p = 0.001, p = 0.04, p = 0.04, p = 0.01, respectively) while
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Wide Aperture was a Hong Kong action film directed by John Woo starring a then-unknown Chow Yun-fat and Nancy Kwan and later remade in 1994 under the English title “Jade Tiger”.
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As the film begins, a gang of illegal drug traffickers, led by a right-wing militant Kwan (Chow Yun-fat) and his assistant, a younger woman named Jay Wada (Nancy Kwan), are awaiting the arrival of their financier, Yosano (Ichiro Fujiyama). Their representative, a large man named Ho (Hwaing Kim), is the only one holding back from attacking the new arrivals, so that he can lay low among the truck drivers and wait for the money. Soon, Yosano arrives with his bodyguard, a young, lithe man named Yamaguchi (Joe Hong).
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